We perform research in different areas of computational biology, in a comparative, evolutionary fashion. With an emphasis on understanding how protein structure and function have shaped the genomic sequence library of today, we pursue projects aimed at elucidating novel mechanisms of molecular evolution that contribute to biological divergence among and within a species. Thus, we travel back in time reconstructing the evolutionary history of protein families. As we gain insights from the past, we look to the future.
Currently, we are investigating how intrinsic disorder evolves, the evolutionary dynamics of protein structure, and how the interplay between different structural and functional properties influences observed amino acid substitutions. Ultimately, we aim to better predict the functional effect of non-synonymous substitutions.
We are studying how the genomes of i) Flavivirus, such as Zika, Dengue and West Nile Virus, ii) HIV, and iii) Influenza viruses evolve on the proteome level in order to inform the development of broadly neutralizing antibodies and antivirals for present day and emerging viral strains.
We are developing novel applications for an integrated analysis of protein sequence data illuminating structural and functional charateristics in an evolutionary context, targeted to the non-bioinformatician user.
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