The Siltberg-Liberles Lab
Evolution of Protein Structure and Function
conformational flexibility, functional divergence, and molecular mimicry
October 19, 2016
Avoiding regions symptomatic of conformational and functional flexibility to identify antiviral targets in current and future coronaviruses
Rahaman and Siltberg-Liberles published in GBE: Genome Biol Evol (2016)doi: 10.1093/gbe/evw246
August 13, 2016
Disorder is not conserved among tyrosine kinase paralogs
Paralog-specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3-SH2-Tyrosine Kinase Protein Family
Helena G. Dos Santos; Jessica Siltberg-Liberles
Genome Biology and Evolution 2016;
May 05, 2016
Disordered sites with secondary structure are the most constrained
The Nuanced Interplay of Intrinsic Disorder and other Structural Properties Driving Protein Evolution
J. Ahrens; H. G. Dos Santos; J. Siltberg-Liberles
Molecular Biology and Evolution 2016;
March 30, 2016
Fellowship to Janelle!
Congratulations on the fellowship, Janelle! We are very proud of you!
March 22, 2016
p53: Guardian or Gambler of the Genome?
Our paper "Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73" was published today in PLoS One: http://dx.doi.org/10.1371/journal.pone.0151961