>Human_SARS_Bcov_spike
----MFIFLLFLTLT----------------SGSDLDRCTTFDDVQAP-----NYTQHTSSMRGVYYP-DEI
FRSDTLYLTQDLFLPF---YSNVTGFHTINHT-------FGNPVIP----FKDGIYFAATEKSNV-------
----------VRGWVFGSTMNNKS---------QSVIIINN------------STNVVIRAC----------
-------NFELCDNPFFAV----SKPMGTQTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLREFVFKN
KDGF--LYVYKGYQPIDVV--RDLPSGFNTLKPIFKLPLGINITNFRAILT-----AFSPAQDI---WGTSA
AAYF---VGYLKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVV-RFP
NITNLCPFGE----VFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCY-GVSATKLNDLCFSNVYA
DSFVVKGDDVRQIAPG--QTGVIADYNYKLPDDFMGCVLAWNTRNID--------ATSTGNYNY--------
------------------------------KYRYLRHGKLRPFER------DISNVP--------FSPDGKP
------------CTP------PALNCYW-----------------------------------PLN----DY
GFYTTTGIGYQP---YRVVVLSFELLNAPATVCGPKLSTDLI--KNQCVNFNFNGLTGTGVLTPSSKRFQ-P
FQQFGRDVSDFTDSVRDPKTSEILDISPCAFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAW
RIYSTGNNV--FQTQAG--CLIGAEHVDTS--YECDIPIGAGICASYHTVS-----LLRSTSQKSIVAYTMS
LGADSSIAYSNNT---------IAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCT
QLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFG-GF-----NFSQILP----DPLKPTKRSFIEDLLF
NKVTLADAGFMKQ-YGECL--GDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGA
ALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTST--------------ALGKLQD
VVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASA
NLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEG---KAYFPR
EGVFVFNGTS-----WFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPEL--DSFKEELDKYF
KNHTS-PDVDLG-DISGINASVVNIQKEID--------------RLNEVAKNLNESLIDLQELGKYEQYIKW
PWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKG-ACSCGSCCKFDEDDSEPVLKGVKLHYT
>Human_OC43_Bcov_spike
----MFLILLISLPT-AFAVIGD--------LKCTSDNINDKDTGPPPIS---TDTVDVTNGLGTYYVLDRV
YLNTTLFLNG--YYPT---SGSTYRNMALKGSVLLSRLWFKPPFLSD---FINGIFAKVKNTKVIKDRVMYS
E---------FPAITIGSTFVNTS---------YSVVVQPRTINSTQDGDNKLQGLLEVSVC----------
-------QYNMCEYPQTIC---HPNLGNHRKELWHLDTGVVSCL-YKRN------------------FTYDV
NADYLYFHFYQEGGTFYAY---FTDTGVVTKF-LFNVYLGMALSHYYVMPL--TCNSKLT------------
LEYW---VTPLTSRQYLLAFNQDGIIFNAVDCMSDFMSEIKCKTQSIAPPTGVYELNGYTVQPIADVYRRKP
NLPN-CNIEA----WLNDKSVPSPLNWERKTFSNCNFNMSSLMSFIQADSFTCN-NIDAAKIYGMCFSSITI
DKFAIPNGRKVDLQLG--NLGYLQSFNYRIDTTATSCQLYYNLPAANVSVSRFNPSTWNKRFGFIEDSVFKP
RPAGVLTNHDVVYAQHCFKAPKNFCPC---KLNGSCVGSGPGKNN------GIGTCP----AGTNYLTCDNL
------------CTPDPITFTGTYKCPQTKSLVGIGEHCSGLAVKSDYCG------GNSCTCRPQAFLGWSA
DS-CLQGDKCNI---FANFILHDVNSGLTCSTDLQKANTDII--LGVCVNYDLYGILGQGIFVEVNATYYNS
WQNLLYDSNGNLYGFRDYITNRTFMIRSCYSGRVSAAF--HANSSEPALLFRNIKCNYVFN--------NSL
TRQLQPINY--FDSYLG--CVVNAYNSTAISVQTCDLTVGSGYCVDY-----SKNRRSRGAITTGYRFTNF-
--EPFTVNSVNDSLEPVGGLYEIQIPSEFTIGNMVEFIQTSSPKVTIDCAAFVCGDYAACKSQLVEYGSFCD
NINAILTEVNELLDTTQLQVANSLMNGVTLSTKLKDGVNFNVDDINFSPVLGCLGSECSKASSRSAIEDLLF
DKVKLSDVGFVEA-YNNCT--GGAEIRDLICVQSYKGIKVLPPLLSENQISGYTLAATSASLFPPWTAA---
-AGVPFYLNVQYRINGLGVTMDVLSQNQKLIANAFNNALYAIQEGFDATNS--------------ALVKIQA
VVNANAEALNNLLQQLSNRFGAISASLQEILSRLDALEAEAQIDRLINGRLTALNAYVSQQLSDSTLVKFSA
AQAMEKVNECVKSQSSRINFCGNGNHIISLVQNAPYGLYFIHFSYVPTKYVTARVSPGLCIAGD--RGIAPK
SGYFVNVNNT-----WMYTGSGYYYPEPITENNVVVMSTCAVNYTKAPYVMLNTSIPNL--PDFKEELDQWF
KNQTS-VAPDL--SLDYINVTFLDLQVEMN--------------RLQEAIKVLNQSYINLKDIGTYEYYVKW
PWYVWLLICLAGVAMLVLLFFICCCTGCGTSCFK---KCGGCCD-DYTGY-QELVIKTSHDD
>Human_SARS2_Bcov_spike
----MFVFLVLLPL-----------------VSSQCVNLTTRTQLPPAYT--------NSFTRGVYYP-DKV
FRSSVLHSTQDLFLPF---FSNVTWFHAIHVSGTNGTKRFDNPVLP----FNDGVYFASTEKSNI-------
----------IRGWIFGTTLDSKT---------QSLLIVNN------------ATNVVIKVC----------
-------EFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKN
IDGY--FKIYSKHTPINLV--RDLPQGFSALEPLVDLPIGINITRFQTLLA--LHRSYLTPGDSSSGWTAGA
AAYY---VGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIV-RFP
NITNLCPFGE----VFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCY-GVSPTKLNDLCFTNVYA
DSFVIRGDEVRQIAPG--QTGKIADYNYKLPDDFTGCVIAWNSNNLD--------SKVGGNYNY--------
------------------------------LYRLFRKSNLKPFER---------DIS-----TEIYQAGSTP
------------CNG-----VEGFNCYF-----------------------------------PLQ----SY
GFQPTNGVGYQP---YRVVVLSFELLHAPATVCGPKKSTNLV--KNKCVNFNFNGLTGTGVLTESNKKFL-P
FQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTW
RVYSTGSNV--FQTRAG--CLIGAEHVNNS--YECDIPIGAGICASYQTQT-NSPRRARSVASQSIIAYTMS
LGAENSVAYSNNS---------IAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCT
QLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFG-GF-----NFSQILP----DPSKPSKRSFIEDLLF
NKVTLADAGFIKQ-YGDCL--GDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGA
ALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTAS--------------ALGKLQD
VVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASA
NLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDG---KAHFPR
EGVFVSNGTH-----WFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPEL--DSFKEELDKYF
KNHTS-PDVDLG-DISGINASVVNIQKEID--------------RLNEVAKNLNESLIDLQELGKYEQYIKW
PWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKG-CCSCGSCCKFDEDDSEPVLKGVKLHYT
>Human_229E_Acov_spike
----MFVLLVA-------------------------------------------------------------
------------------------------------------------------------------------
-----------------------------------------------------YALLHIAGC----------
-------Q--------------------TTNGLNTSYSVCNGCVGYSENVFAVESGGYIPSD-----FAFNN
---W--FLLTNTSSVVDGVVRSFQPLLLNCLWSVSGLRFTTGFVYFNGTGRG-DCKGFSSDVLSD--VIRYN
LNFE----ENLRRGTILFKTSYGVVVFYCTNNTLVSG-DAHIPFGTVLGNFYCFVNTTIGNETTSAFVGALP
KTVREFVISRTGHFYINGYRYFTLGNVEAVNFNVTTAETTDFCTVALASYADVLVNVSQTSIANIIYCNSVI
NRLRC-DQLSFDVPDGFYSTSPIQSV--ELPVSIVSLPVYHKHTFIVLYVDFKPQSGGGKCFNCYPAGVNIT
LANFNETKGPLCVDTSHFTT----------KYVAVYANVGRWSAS-----INTGNCPFSFGKVNNFVKFGSV
------------CFS---LKDIPGGCAM-----------------------------------PIV-ANWAY
SKYYTIG---SL---YVSWSDGDGITGVPQPVEGVSSFMNVT--LDKCTKYNIYDVSGVGVIRVSNDTFLNG
ITYT--STSGNLLGFKDVTKGTIYSITPCNPPDQLVVY----QQAVVGAMLSENFTSYGFS-----------
NVVELPKFF--YASNGTYNCTDAVLTYSSF-----------GVCADGSIIA-VQPRNVSYDSVSAIVTAN--
----------------------LSIPSNWTTSVQVEYLQITSTPIVVDCSTYVCNGNVRCVELLKQYTSACK
TIEDALRNSARLESADVSEMLTFDKKAFTLANVSSFG-DY-----NLSSVIPSLPTSGSRVAGRSAIEDILF
SKLVTSGLGTVDADYKKCT--KGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGIALGGLTSA---
-VSIPFSLAIQARLNYVALQTDVLQENQKILAASFNKAMTNIVDAFTGVNDAITQTSQALQTVATALNKIQD
VVNQQGNSLNHLTSQLRQNFQAISSSIQAIYDRLDTIQADQQVDRLITGRLAALNVFVSHTLTKYTEVRASR
QLAQQKVNECVKSQSKRYGFCGNGTHIFSIVNAAPEGLVFLHTVLLPTQYKDVEAWSGLCVDGT--NGYVLR
QPNLALYKEGNY---YRITSRIMFEPRIPTMADFVQIENCNVTFVNISRSELQTIVPEY--IDVNKTLQELS
YKLPNYTVPDL--VVEQYNQTILNLTSEISTLENKSAELNYTVQKLQTLIDNINSTLVDLKWLNRVETYIKW
PWWVWLCISVVLIFVVSMLLLCCCSTGCCGFFSCFASSIRGCCE--STKL-PYYDVEKIHIQ
>Human_MERS_Bcov_spike
MIHSVFLLMFLLTPTESYVDVGPDS------VKSACIEVDIQQTFFDKTW---PRPIDVSKADGIIYPQGRT
YSNITITYQG--LFPYQGDHGDMYVYSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIIS
PSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGC----------GTLLRAFYCILEPRSGNHC
PAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTYN------------------ITEDE
ILEW--FGITQTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIPH--SIRSIQSDRKA---W----
AAFY---VYKLQPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAE
GVE--CDFSP----LLSGTP-PQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCS-QISPAAIASNCYSSLIL
DYFSYPLSMKSDLSVS--SAGPISQFNYKQSFSNPTCLILATVPH--------NLTTITKPLKY--------
------------------------------SYINKCSRLLSDDRT---------EVP-QLVNANQYSPCVSI
------------VPS---TVWEDGDYYRKQLS-------------------------------PLEGGGWLV
ASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGV-R
QQRFVYDAYQNLVGYYS-DDGNYYCLRACVSVPVSVIY--DKETKTHATLFGSVACEHISSTMSQYSRSTRS
MLKRRDSTYGPLQTPVG--CVLGLVNSSLF-VEDCKLPLGQSLCALPDTPSTLTPRSVR-SVPGEMRLASIA
FNHPIQVDQLNSS------YFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCS
KINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDF-----NLTLLEPVSISTGSR-SARSAIEDLLF
DKVTIADPGYMQG-YDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSS
FAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNE--------------AFQKVQD
AVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSA
QLAKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPV
NGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKYVAP-QVTYQNISTNLPPPLLGNSTGIDFQDELDEFF
KNVST-SIPNFG-SLTQINTTLLDLTYEML--------------SLQQVVKALNESYIDLKELGNYTYYNKW
PWYIWLGFIAGLVALALCVFFILCCTGCGTNCMG-KLKCNRCCD-RYEEY--DLEPHKVHVH
>Human_NL63_Acov_spike
--MKLFLILLVLPLASCFFTCNSNANLSMLQLGVPDNSSTIVTGLLPTHWFCANQSTSVYSANGFFYIDVGN
HRSAFALHTG--YYDANQYYIYVTNEIGLNASVTLKICKFSRNTTFD-------FLSNASSSFDCIVNLLFT
EQLGAPLGITISGETVRLHLYNVT---------RTFYVPAA------------YKLTKLSVK----------
-------CYFNYSCVFSVVNATVTVNVTTHNGRVVNYTVCDDCNGYTDNIFSVQQDGRIPNG-----FPFNN
---W--FLLTNGSTLVDGVSRLYQPLRLTCLWPVPGLKSSTGFVYFNATGSDVNCNGYQHNSVVD--VMRYN
LNFSANSLDNLKSGVIVFKTLQYDVLFYCSNSSSGVL-DTTIPFGPSSQPYYCFINSTINTTHVSTFVGILP
PTVREIVVARTGQFYINGFKYFDLGFIEAVNFNVTTASATDFWTVAFATFVDVLVNVSATNIQNLLYCDSPF
EKLQC-EHLQFGLQDGFYSANFLDDN--VLPETYVALPIYYQHTDINFTA---TASFGGSCYVCKPHQVNIS
LNG----NTSVCVRTSHFSI----------RYIYNRVKSGSPGDSSWHIYLKSGTCPFSFSKLNNFQKFKTI
------------CFS---TVEVPGSCNF-----------------------------------PLE-ATWHY
TSYTIVG---AL---YVTWSEGNSITGVPYPVSGIREFSNLV--LNNCTKYNIYDYVGTGIIRSSNQSLAGG
ITYV--SNSGNLLGFKNVSTGNIFIVTPCNQPDQVAVY----QQSIIGAMTAVNESRYGLQ-----------
NLLQLPNFY--YVSNGGNNCTTAVMTYSNF-----------GICADGSLIP-VRPRNSSDNGISAIITAN--
----------------------LSIPSNWTTSVQVEYLQITSTPIVVDCATYVCNGNPRCKNLLKQYTSACK
TIEDALRLSAHLETNDVSSMLTFDSNAFSLANVTSFG-DY-----NLSSVLPQRNIRSSRIAGRSALEDLLF
SKVVTSGLGTVDVDYKSCT--KGLSIADLACAQYYNGIMVLPGVADAERMAMYTGSLIGGMVLGGLTSA---
-AAIPFSLALQARLNYVALQTDVLQENQKILAASFNKAINNIVASFSSVNDAITQTAEAIHTVTIALNKIQD
VVNQQGSALNHLTSQLRHNFQAISNSIQAIYDRLDSIQADQQVDRLITGRLAALNAFVSQVLNKYTEVRGSR
RLAQQKINECVKSQSNRYGFCGNGTHIFSIVNSAPDGLLFLHTVLLPTDYKNVKAWSGICVDGI--YGYVLR
QPNLVLYSDNGV---FRVTSRVMFQPRLPVLSDFVQIYNCNVTFVNISRVELHTVIPDY--VDVNKTLQEFA
QNLPKYVKPNF--DLTPFNLTYLNLSSELKQLEAKTASLFQTTVELQGLIDQINSTYVDLKLLNRFENYIKW
PWWVWLIISVVFVVLLSLLVFCCLSTGCCGCCNCLTSSMRGCCDCGSTKL-PYYEFEKVHVQ
>Human_HKU1_Bcov_spike
----MLLIIFILPTT--LAVIGD--------FNCTNFAINDLNTTVPRIS---EYVVDVSYGLGTYYILDRV
YLNTTILFTG--YFPK---SGANFRDLSLKGTTYLSTLWYQKPFLSD---FNNGIFSRVKNTKLYVNKTLYS
E---------FSTIVIGSVFINNS---------YTIVVQPH------------NGVLEITAC----------
-------QYTMCEYPHTIC----KSKGSSRNESWHFDKSEPLCL-FKKN------------------FTYNV
STDWLYFHFYQERGTFYAY---YADSGMPTTF-LFSLYLGTLLSHYYVLPL--TCNAISSNTDNE------T
LQYW---VTPLSKRQYLLKFDNRGVITNAVDCSSSFFSEIQCKTKSLLPNTGVYDLSGFTVKPVATVHRRIP
DLPD-CDIDK----WLNNFNVPSPLNWERKIFSNCNFNLSTLLRLVHTDSFSCN-NFDESKIYGSCFKSIVL
DKFAIPNSRRSDLQLG--SSGFLQSSNYKIDTTSSSCQLYYSLPAINVTINNYNPSSWNRRYGF--------
-NNFNLSSHSVVYSRYCFSVNNTFCPCAKPSFASSCKSHKPPSAS----------CP----IGTNYRSCEST
TVLDHTDWCRCSCLPDPITAYDPRSCSQKKSLVGVGEHCAGFGVDEEKCGVLDGSYNVSCLCSTDAFLGWSY
DT-CVSNNRCNI---FSNFILNGINSGTTCSNDLLQPNTEVF--TDVCVDYDLYGITGQGIFKEVSAVYYNS
WQNLLYDSNGNIIGFKDFVTNKTYNIFPCYAGRVSAAF--HQNASSLALLYRNLKCSYVLN-----------
NISLTTQPY--FDSYLG--CVFNADNLTDYSVSSCALRMGSGFCVDYNSPSSSSSRRKRRSISASYRFVTF-
--EPFNVSFVNDSIESVGGLYEIKIPTNFTIVGQEEFIQTNSPKVTIDCSLFVCSNYAACHDLLSEYGTFCD
NINSILDEVNGLLDTTQLHVADTLMQGVTLSSNLNTNLHFDVDNINFKSLVGCLGPHCGS-SSRSFFEDLLF
DKVKLSDVGFVEA-YNNCT--GGSEIRDLLCVQSFNGIKVLPPILSESQISGYTTAATVAAMFPPWSAA---
-AGIPFSLNVQYRINGLGVTMDVLNKNQKLIATAFNNALLSIQNGFSATNS--------------ALAKIQS
VVNSNAQALNSLLQQLFNKFGAISSSLQEILSRLDALEAQVQIDRLINGRLTALNAYVSQQLSDISLVKFGA
ALAMEKVNECVKSQSPRINFCGNGNHILSLVQNAPYGLLFMHFSYKPISFKTVLVSPGLCISGD--VGIAPK
QGYFIKHNDH-----WMFTGSSYYYPEPISDKNVVFMNTCSVNFTKAPLVYLNHSVPKL--SDFESELSHWF
KNQTS-IAPNLTLNLHTINATFLDLYYEMN--------------LIQESIKSLNNSYINLKDIGTYEMYVKW
PWYVWLLISFSFIIFLVLLFFICCCTGCGSACFS---KCHNCCD-EYGGH-HDFVIKTSHDD